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KMID : 1037820150040020037
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Journal of Pain and Autonomic Disorders
2015 Volume.4 No. 2 p.37 ~ p.44
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Clinical Understanding of Endogenous Opioid
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Lee Dong-Kuck
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Abstract
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The endogenous opioid system includes a large number of opioid peptides that are ligands for numerous types of opioid receptors. Three distinct families of endogenous peptides have been well characterized-endorphin, enkephalin and dynorphin. More recently, two additional short peptides, endomorphin-1 and endomorphin-2 that display a high affinity and selectivity for mu opioid receptors have been identified. The endogenous opioid peptides bind to three primary opioid receptor types that mediate analgesia.
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KEYWORD
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Endogenous opioid, Endorphin, Enkephalin, Dynorphin, Endomorphin
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